anti- CDK6 antibody

Size

2X100μg

Catalog no#

FNab01561

Price

320 EUR

Synonyms

CDKN6

Uniprot ID

Q00534

Calculated MW

37 kDa

Form

liquid

French translation

anticorps

Specificity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF

Immunogen

cyclin-dependent kinase 6

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Recommended dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Image4

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab01561(CDK6 antibody) at dilution of 1:1000

Image1

Immunohistochemistry of paraffin-embedded human endometrial cancer using FNab01561(CDK6 antibody) at dilution of 1:50

Properties

If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.

Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.