anti- NFKB1 antibody

Size

2X100μg

Catalog no#

FNab05702

Price

320 EUR

Specificity

Human

Uniprot ID

P19838

Form

liquid

Calculated MW

120 kDa

French translation

anticorps

Tested Application

ELISA, WB, IHC, IF, IP

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Immunogen

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Recommended dilution

WB: 1:500 - 1:1000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100; IP: 1:20 - 1:50

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Properties

If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.

Background

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.